Norifumi Kawada Selected Research

Cytoglobin

5/2022	Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.
1/2021	Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
11/2020	Cytoglobin-expressing cells in the splenic cords contribute to splenic fibrosis in cirrhotic patients.
10/2020	TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
1/2020	The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease.
1/2020	Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.
12/2018	Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice.
10/2017	The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
1/2017	Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.
3/2016	Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.

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Norifumi Kawada Research Topics

Disease

53	Fibrosis (Cirrhosis) 05/2022 - 05/2003
40	Liver Cirrhosis (Hepatic Cirrhosis) 05/2022 - 11/2002
39	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 03/2002
34	Infections 09/2022 - 04/2006
30	Chronic Hepatitis C 01/2021 - 10/2003
26	Neoplasms (Cancer) 05/2022 - 02/2007
19	Chronic Hepatitis B 01/2022 - 02/2005
19	Liver Diseases (Liver Disease) 01/2022 - 03/2006
16	Non-alcoholic Fatty Liver Disease 01/2021 - 03/2006
15	Hepatitis 01/2021 - 05/2003
9	Fatty Liver 01/2021 - 03/2007
8	Carcinogenesis 01/2022 - 08/2011
7	Necrosis 01/2021 - 02/2003
7	Inflammation (Inflammations) 01/2021 - 01/2009
6	Chronic Hepatitis (Chronic Active Hepatitis) 03/2016 - 04/2007
5	Hepatitis B 01/2019 - 12/2008
4	Cholestasis 02/2021 - 01/2017
4	Alcoholic Fatty Liver 10/2020 - 03/2011
4	Virus Diseases (Viral Diseases) 07/2020 - 01/2013
4	Disease Progression 06/2014 - 03/2006
4	Insulin Resistance 03/2012 - 03/2007
3	Hypoxia (Hypoxemia) 08/2019 - 05/2013
3	Neoplasm Metastasis (Metastasis) 02/2017 - 06/2012
2	Pancreatic Neoplasms (Pancreatic Cancer) 05/2022 - 01/2018
2	Hepatic Encephalopathy 01/2022 - 05/2018
2	Hemorrhage 01/2021 - 01/2021
2	Cholangiocarcinoma 12/2020 - 07/2014
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2020 - 12/2019
2	Hypertension (High Blood Pressure) 08/2019 - 10/2017
2	Ascites 05/2018 - 03/2012
2	Headache (Headaches) 01/2018 - 06/2014
2	Nasopharyngitis 01/2018 - 06/2014
2	Anemia 08/2017 - 01/2015

Drug/Important Bio-Agent (IBA)

27	InterferonsIBA 12/2019 - 03/2007
24	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2009
17	CytoglobinIBA 05/2022 - 02/2007
13	Biomarkers (Surrogate Marker)IBA 07/2021 - 02/2011
12	Ribavirin (Virazole)FDA LinkGeneric 01/2018 - 01/2008
11	CollagenIBA 07/2021 - 10/2003
11	Thioacetamide (Thioacetamid)IBA 01/2021 - 05/2003
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2002
9	entecavir FDA Link 05/2019 - 12/2008
8	GlobinsIBA 01/2022 - 08/2011
8	Amino Acids FDA Link 01/2021 - 06/2004
8	MicroRNAs (MicroRNA)IBA 12/2020 - 11/2012
7	lenvatinibIBA 02/2021 - 08/2019
7	Choline (Choline Chloride)IBA 01/2021 - 02/2010
6	Biological ProductsIBA 01/2022 - 03/2011
6	Hepatitis B Surface Antigens (HBsAg)FDA Link 02/2021 - 02/2005
6	Transforming Growth Factors (Transforming Growth Factor)IBA 11/2020 - 06/2012
6	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 11/2007
6	Messenger RNA (mRNA)IBA 01/2017 - 03/2007
6	Lamivudine (Epivir)FDA Link 08/2015 - 02/2005
5	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2022 - 10/2003
5	Alanine Transaminase (SGPT)IBA 01/2021 - 01/2009
5	AntigensIBA 01/2019 - 03/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2022 - 01/2020
4	NucleosidesIBA 01/2022 - 09/2008
4	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2008
4	Pharmaceutical PreparationsIBA 02/2021 - 10/2006
4	Indicators and Reagents (Reagents)IBA 01/2021 - 11/2011
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2021 - 01/2009
4	Methionine (L-Methionine)FDA Link 01/2021 - 11/2007
4	Tenofovir (Viread)FDA Link 01/2020 - 04/2013
4	CytokinesIBA 12/2018 - 03/2007
4	Hepatitis B e AntigensIBA 05/2018 - 09/2008
4	CholesterolIBA 06/2012 - 03/2007
3	Cysteine (L-Cysteine)FDA Link 05/2022 - 11/2002
3	AlbuminsIBA 04/2022 - 02/2003
3	Immune Checkpoint ProteinsIBA 01/2022 - 01/2020
3	nasIBA 02/2021 - 01/2009
3	LipidsIBA 01/2021 - 03/2012
3	Collagen Type IV (Type IV Collagen)IBA 01/2021 - 02/2011
3	Carrier Proteins (Binding Protein)IBA 06/2020 - 10/2013
3	Sorafenib (BAY 43-9006)FDA Link 01/2020 - 01/2013
3	Insulin (Novolin)FDA Link 08/2019 - 02/2011
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2018 - 04/2006
3	Branched-Chain Amino AcidsIBA 05/2018 - 07/2009
3	Hemoglobins (Hemoglobin)IBA 10/2017 - 03/2007
3	Monoclonal AntibodiesIBA 01/2013 - 03/2002
3	halofuginoneIBA 10/2010 - 02/2007
3	Transforming Growth Factor beta (TGF-beta)IBA 05/2009 - 07/2005
3	AntibodiesIBA 01/2009 - 03/2002
3	ThioredoxinsIBA 01/2005 - 05/2003
2	AntioxidantsIBA 05/2022 - 01/2021
2	SofosbuvirIBA 01/2021 - 01/2018
2	3-nitrotyrosineIBA 11/2020 - 08/2011
2	sofosbuvir drug combination ledipasvirIBA 10/2020 - 01/2018
2	wisteria lectinIBA 06/2020 - 10/2017
2	NitrogenIBA 01/2020 - 05/2018
2	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2020 - 08/2011
2	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2020 - 12/2019
2	Fetal Proteins (Fetoprotein)IBA 05/2019 - 01/2017
2	Transaminases (Aminotransferases)IBA 11/2018 - 09/2003
2	Indocyanine Green (Cardio-Green)FDA LinkGeneric 09/2018 - 01/2017
2	Nucleic AcidsIBA 01/2017 - 10/2016

Therapy/Procedure

63	Therapeutics 01/2022 - 10/2003
5	Aftercare (After-Treatment) 01/2021 - 01/2013
4	Ligation 01/2021 - 02/2008
2	Liver Transplantation 07/2021 - 07/2009